Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma

ALK- negative Anaplastic Large Cell Lymphoma of Bone

IL 22 ( interleukin 22 )

alk- negative anaplastic large cell lymphoma of bone

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IL-22 vs. IL-22: The Tissue Matters

IL-22 is a cytokine recently discovered to be produced by TH17 cells. Its receptor is expressed in the skin, liver, the digestive and the respiratory tract where IL-22 conveys signals of the immune system directly to the tissue. IL-22 is involved in the host defense against extracellular pathogens as well as in autoimmune inflammatory diseases and exerts, depending on the tissue and inflammator...

Pathobiology of ALK+ anaplastic large-cell lymphoma.

Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic features and the consistent expression of CD30. It then became evident that the majority of these tumors are derived from lymphoid cells of T or null immunophenotype. The subsequent finding that t(2;5)(p23;q35) occurs in 40% to 60% of ALCL patients established a distinct clinicopathologic entity. This chr...